Endocrine Abstracts

Purpose: This retrospective study is intended to determine the dose of radioactive iodine using thyroglobulin levels measured after two weeks of thyroid hormone withdrawal in patients with differentiated thyroid cancer. Methods : Patients who were diagnosed as differentiated thyroid cancer and treated with radioiodine after total thyroidectomy were enrolled. Serum thyroglobulin test (preTG; ng/dl) was performed 1 week before radioiodine treatment and 2 w...

Purpose: This retrospective study is evaluated the efficacy of three doses of I-131 (1110 MBq vs 3700 MBq vs 5550 MBq) in differentiated thyroid carcinoma patients with cut-off serum thyroglobulin (TG) level after two weeks of thyroid hormone withdrawal for postoperative thyroid remnant ablation.Methods: A total of 97 patients with differentiated thyroid cancer treated with total thyroidectomy and radioactive iodine (RAI) therapy...

Hypertriglyceridemia (HTG) is known to be a risk factor for cardiovascular diseases, such as atherosclerosis and hypertension. Although the association between insulin resistance (IR) and HTG has long been recognized, the causal relationship between them has not been elucidated yet. Proper understanding of the effect of IR on HTG may better start with the realization that IR implies much more than mere impairment of glucose uptake in tissues. Given that the role of insulin is ...

Objective: The aim of the present study was to determine the plasma osteoprotegerin (OPG) levels in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) during the last trimester of pregnancy, and to investigate the relationship between OPG and some related factors.Method: In this study, 65 women with GDM and 65 women with NGT were enrolled. Plasma concentration of OPG was measured by enzyme linked immunosorbent assay (ELISA)...

Insulin resistance (IR) may be defined as the physiological condition, in which insulin signaling is somehow deranged somewhat irreversibly such that insulin is of little use to cells or tissues. Specific roles of insulin are quite different in the muscle tissue, adipose tissue, and liver. Accordingly, detailed aspects of IR would be very tissue-specific. Meanwhile, IR may develop first in the muscle tissue with a relatively low cell turnover and then progress, in sequence, to...

Background: Confirmatory tests, including saline infusion test (SIT), captopril challenge test (CCT) and fludrocortisone suppression test (FST) are commonly used for diagnosis of primary aldosteronism (PA). Each test has its advantages and disadvantages, but which one should be preferentially performed is controversial. We aimed to evaluate the diagnostic accuracy of three tests in a prospective study.Methods: Five hundred and thirty-one hypertensive pat...

Uncontrolled hyperglycemia accelerates endothelial damage and vascular inflammation caused by proinflammatory cytokines including tumor necrosis factor α (TNFα), which leads to arteriosclerotic cardiovascular diseases. Glycogen synthase kinase 3β (GSK3β) is reported to mediate TNFα-stimulated nuclear factor-κB (NF-κB) activation and expression of vascular adhesion molecules. Although a few clinical trials have suggested that telmisartan, an a...

Uncontrolled hyperglycemia accelerates endothelial damage and vascular inflammation caused by proinflammatory cytokines including tumor necrosis factor α (TNFα), which leads to arteriosclerotic cardiovascular diseases. Glycogen synthase kinase 3β (GSK3β) is reported to mediate TNFα-stimulated nuclear factor-κB (NF-κB) activation and expression of vascular adhesion molecules. Although a few clinical trials have suggested that telmisartan, an a...

Elongation factor, RNA polymerase II, 2 (ELL2) is an RNA Pol II elongation factor with functional properties similar to ELL that can interact with the prostate tumor suppressor ELL-associated factor 2 (EAF2). In murine models, deletion of Ell2 induced prostate intraepithelial neoplasia similar to that induced by deletion of Eaf2. Since ELL2 and EAF2 can functionally interact and appear to have similar function in regulating prostate homeostasis, we investigated the impact of c...

The morning serum cortisol measurement has long been used as an index of adrenal function in the unstressed patient, but does not necessarily differentiate normal subjects from those with adrenal dysfunction. We investigate causes and clinical findings of adrenocortical insufficiency in this study, and will propose a model predicting results of rapid ACTH stimulation test. A consecutive series of 363 subjects who were examined rapid ACTH stimulation were recruited. Adrenocorti...